Chemical name: Phenol, 2-(1-methylpropyl)-4,6-dinitro- Final regulatory action has been taken for the category: Pesticide Final regulatory action: The chemical is Banned Use or uses prohibited by the final regulatory action: All formulations and uses are prohibited. Pesticide use or uses that remain allowed: None The final regulatory action was based on a risk or hazard evaluation: No Summary of the final regulatory action: Dinoseb was excluded from the list of active substances authorized for use in plant protection products in 1984 under the Law on protection of plants against pests and blights. It has prohibited to production, use and place on the market all plant protection products containing Dinoseb since 2004, according to annual adopted list of active ingredients banned for use in plant protection products under the lant Protection Act. Dinoseb is designated as a PIC chemical. (Annex I of the Regulation on the import and export of certain dangerous chemicals on the Bulgarian territory). The import and use of the chemical for research or laboratory purposes in quantities less than 10 kg are allowed. The reasons for the final regulatory action were relevant to: Human health and environment Summary of known hazards and risks to human health: Pure dinoseb is considered highly toxic to mammals and is lethal when fed to rodents at high levels. Poisoning and death have occurred in humans after intentional ingestions of concentrated dinoseb and after heavy skin contamination by agricultural sprays. Dinoseb can be absorbed by skin contact, inhalation, or ingestion. Bathing in or drinking contaminated water can lead to absorption. Once in the body, it can distribute widely and cross the placental membrane. It is metabolized by the liver and excreted in the feces and, to a lesser extent, in the urine. Elimination of dinoseb from the human body is gradual. Dinoseb can build up in blood and tissues if daily exposures exceed the amount eliminated daily. Early warning signs of dinoseb exposure are sweating, fever, malaise, and headache. Dinoseb intoxication may also cause thirst, insomnia, nausea, weight loss, and mood changes. Warm flushed skin, rapid heart rate, quick shallow breathing, and convulsions are signs of serious life-threatening poisoning. A small percentage of people exposed to dinoseb have complained of skin rashes, but the rashes have not been directly linked to the amount of exposure. Skin contact may cause yellow staining or inflammation of the skin. Repeated exposure for long periods of time can lead to liver and kidney problems. It may also cause decreased fertility in adults, birth defects, and developmental changes in a growing fetus. Dinoseb is not listed as a human cancer-causing agent by EPA. It is classified as a group D compound ("not classifiable") because the cancer tests, although negative, are not considered adequate by today's standards. Expected effect of the final regulatory action in relation to human health: Decrease of hazards and risks to human health. Summary of known hazards and risks to the environment: Effects on birds: The compound is very highly toxic to birds, with reported acute oral LD50 values between 7 and 9 mg/kg; its reported 5- to 8-day dietary LC50 ranges from 409 ppm in quail to 515 ppm in pheasants. It thus has the potential to negatively impact local pheasant and songbird populations. Effects on aquatic organisms: Dinoseb is highly toxic to fish, with reported 96-hour LC50 values ranging from 44ug/L in lake trout to 118ug/L in catfish. Other 96-hour LC50 values are 100ug/L in coho salmon and 67ug/L in cutthroat trout. It is more toxic to fish in acidic water than in neutral or alkaline water. Dinoseb has caused fish kills in small Scottish streams when washed from fields by rain. The bioconcentration factor is 135. Dinoseb is rapidly taken up by fish, but is rapidly eliminated from exposed fish if placed in clean water. Dinoseb, thus, does not pose a significant risk for bioaccumulation. Effects on other organisms: Dinoseb is toxic to bees. Expected effect of the final regulatory action in relation to the environment: To avoid exposure of the chemical and the related risks to the environment. Date of entry into force of the final regulatory action: 01/01/2004 |